[HTML][HTML] IL-21-dependent expansion of memory-like NK cells enhances protective immune responses against Mycobacterium tuberculosis
S Venkatasubramanian, S Cheekatla, P Paidipally… - Mucosal …, 2017 - Elsevier
Natural killer (NK) cells are traditionally considered as innate cells, but recent studies
suggest that NK cells can distinguish antigens, and that memory NK cells expand and
protect against viral pathogens. Limited information is available about the mechanisms
involved in memory-like NK cell expansion, and their role in bacterial infections and vaccine-
induced protective immune responses. In the current study, using a mouse model of
tuberculosis (TB) infection, we found that interferon-gamma producing CD3− NKp46+ …
suggest that NK cells can distinguish antigens, and that memory NK cells expand and
protect against viral pathogens. Limited information is available about the mechanisms
involved in memory-like NK cell expansion, and their role in bacterial infections and vaccine-
induced protective immune responses. In the current study, using a mouse model of
tuberculosis (TB) infection, we found that interferon-gamma producing CD3− NKp46+ …