Postmortem findings in Italian patients with COVID-19: a descriptive full autopsy study of cases with and without comorbidities
L Falasca, R Nardacci, D Colombo… - The Journal of …, 2020 - academic.oup.com
The Journal of infectious diseases, 2020•academic.oup.com
Background Descriptions of the pathological features of coronavirus disease-2019 (COVID-
19) caused by the novel zoonotic pathogen severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2) emanate from tissue biopsies, case reports, and small postmortem studies
restricted to the lung and specific organs. Whole-body autopsy studies of COVID-19 patients
have been sparse. Methods To further define the pathology caused by SARS-CoV-2 across
all body organs, we performed autopsies on 22 patients with COVID-19 (18 with …
19) caused by the novel zoonotic pathogen severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2) emanate from tissue biopsies, case reports, and small postmortem studies
restricted to the lung and specific organs. Whole-body autopsy studies of COVID-19 patients
have been sparse. Methods To further define the pathology caused by SARS-CoV-2 across
all body organs, we performed autopsies on 22 patients with COVID-19 (18 with …
Background
Descriptions of the pathological features of coronavirus disease-2019 (COVID-19) caused by the novel zoonotic pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emanate from tissue biopsies, case reports, and small postmortem studies restricted to the lung and specific organs. Whole-body autopsy studies of COVID-19 patients have been sparse.
Methods
To further define the pathology caused by SARS-CoV-2 across all body organs, we performed autopsies on 22 patients with COVID-19 (18 with comorbidities and 4 without comorbidities) who died at the National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS Hospital, Rome, Italy. Tissues from the lung, heart, liver, kidney, spleen, and bone marrow (but not the brain) were examined. Only lung tissues were subject to transmission electron microscopy.
Results
COVID-19 caused multisystem pathology. Pulmonary and cardiovascular involvement were dominant pathological features. Extrapulmonary manifestations included hepatic, kidney, splenic, and bone marrow involvement, and microvascular injury and thrombosis were also detected. These findings were similar in patients with or without preexisting medical comorbidities.
Conclusions
SARS-CoV-2 infection causes multisystem disease and significant pathology in most organs in patients with and without comorbidities.
Oxford University Press