Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management

ETH Yeh, CL Bickford - Journal of the American College of Cardiology, 2009 - jacc.org
ETH Yeh, CL Bickford
Journal of the American College of Cardiology, 2009jacc.org
Cancer treatment today employs a combination of chemotherapy, radiotherapy, and surgery
to prolong life and provide cure. However, many of these treatments can cause
cardiovascular complications such as heart failure, myocardial ischemia/infarction,
hypertension, thromboembolism, and arrhythmias. In this article we review the incidence of
cardiotoxicity caused by commonly used chemotherapeutic agents as well as discuss the
pathogenesis, diagnosis, management, and prevention of these cardiovascular side effects …
Cancer treatment today employs a combination of chemotherapy, radiotherapy, and surgery to prolong life and provide cure. However, many of these treatments can cause cardiovascular complications such as heart failure, myocardial ischemia/infarction, hypertension, thromboembolism, and arrhythmias. In this article we review the incidence of cardiotoxicity caused by commonly used chemotherapeutic agents as well as discuss the pathogenesis, diagnosis, management, and prevention of these cardiovascular side effects. Cardiotoxicity related to anticancer treatment is important to recognize as it may have a significant impact on the overall prognosis and survival of cancer patients, and it is likely to remain a significant challenge for both cardiologists and oncologists in the future due to an increasing aging population of patients with cancer and the introduction of many new cancer therapies.
jacc.org