Importance Somatic mutations causing clonal expansion of hematopoietic cells (clonal
hematopoiesis of indeterminate potential [CHIP]) are increased with age and associated
with atherosclerosis and inflammation. Age and inflammation are the major risk factors for
heart failure, yet the association of CHIP with heart failure in humans is unknown. Objective
To assess the potential prognostic significance of CHIP in patients with chronic heart failure
(CHF) owing to ischemic origin. Design, Setting, and Participants We analyzed bone marrow …