Ara h 1–reactive T cells in individuals with peanut allergy
JH DeLong, KH Simpson, E Wambre, EA James… - Journal of Allergy and …, 2011 - Elsevier
Background Effective immunotherapy for peanut allergy is hampered by a lack of
understanding of peanut-reactive CD4+ T cells. Objective To identify, characterize, and track
Ara h 1–reactive cells in subjects with peanut allergy by using Ara h 1–specific class II
tetramers. Methods Tetramer-guided epitope mapping was used to identify the antigenic
peptides within the peanut allergen Ara h 1. Subsequently, HLA class II/Ara h 1–specific
tetramers were used to determine the frequency and phenotype of Ara h 1–reactive T cells in …
understanding of peanut-reactive CD4+ T cells. Objective To identify, characterize, and track
Ara h 1–reactive cells in subjects with peanut allergy by using Ara h 1–specific class II
tetramers. Methods Tetramer-guided epitope mapping was used to identify the antigenic
peptides within the peanut allergen Ara h 1. Subsequently, HLA class II/Ara h 1–specific
tetramers were used to determine the frequency and phenotype of Ara h 1–reactive T cells in …