Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector TH2 subsets

D Chiang, X Chen, SM Jones, RA Wood… - Journal of Allergy and …, 2018 - Elsevier
Background The contribution of phenotypic variation of peanut-specific T cells to clinical
allergy or tolerance to peanut is not well understood. Objectives Our objective was to
comprehensively phenotype peanut-specific T cells in the peripheral blood of subjects with
and without peanut allergy (PA). Methods We obtained samples from patients with PA,
including a cohort undergoing baseline peanut challenges for an immunotherapy trial
(Consortium of Food Allergy Research [CoFAR] 6). Subjects were confirmed as having PA …