[HTML][HTML] IL-17-induced NF-κB activation via CIKS/Act1: physiologic significance and signaling mechanisms
Interleukin-17 (IL-17) is essential in host defense against extracellular bacteria and fungi,
especially at mucosal sites, but it also contributes significantly to inflammatory and
autoimmune disease pathologies. Binding of IL-17 to its receptor leads to recruitment of
adaptor protein CIKS/Act1 via heterotypic association of their respective SEFIR domains and
activation of transcription factor NF-κB; it is not known whether CIKS and/or NF-κB are
required for all gene induction events. Here we report that CIKS is essential for all IL-17 …
especially at mucosal sites, but it also contributes significantly to inflammatory and
autoimmune disease pathologies. Binding of IL-17 to its receptor leads to recruitment of
adaptor protein CIKS/Act1 via heterotypic association of their respective SEFIR domains and
activation of transcription factor NF-κB; it is not known whether CIKS and/or NF-κB are
required for all gene induction events. Here we report that CIKS is essential for all IL-17 …