Natural killer cells in inflammatory heart disease
SF Ong, NR Rose, D Čiháková - Clinical Immunology, 2017 - Elsevier
Despite of a multitude of excellent studies, the regulatory role of natural killer (NK) cells in
the pathogenesis of inflammatory cardiac disease is greatly underappreciated. Clinical
abnormalities in the numbers and functions of NK cells are observed in myocarditis and
inflammatory dilated cardiomyopathy (DCMi) as well as in cardiac transplant rejection
[1],[2],[3],[4],[5],[6]. Because treatment of these disorders remains largely symptomatic in
nature, patients have little options for targeted therapies [7],[8]. However, blockade of NK …
the pathogenesis of inflammatory cardiac disease is greatly underappreciated. Clinical
abnormalities in the numbers and functions of NK cells are observed in myocarditis and
inflammatory dilated cardiomyopathy (DCMi) as well as in cardiac transplant rejection
[1],[2],[3],[4],[5],[6]. Because treatment of these disorders remains largely symptomatic in
nature, patients have little options for targeted therapies [7],[8]. However, blockade of NK …