Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy
SJ Getting - Trends in pharmacological sciences, 2002 - cell.com
SJ Getting
Trends in pharmacological sciences, 2002•cell.comAbstract α-Melanocyte stimulating hormone (α-MSH) and other melanocortin peptides are
potent anti-inflammatory agents that exhibit efficacy in many animal models of acute and
chronic inflammation. These peptides are produced both centrally and peripherally, and
exert their biological actions via activation of membrane-bound receptors. To exploit the
therapeutic potential of such anti-inflammatory peptides, it is essential that the receptor
subtype mediating these effects is identified with certainty.
potent anti-inflammatory agents that exhibit efficacy in many animal models of acute and
chronic inflammation. These peptides are produced both centrally and peripherally, and
exert their biological actions via activation of membrane-bound receptors. To exploit the
therapeutic potential of such anti-inflammatory peptides, it is essential that the receptor
subtype mediating these effects is identified with certainty.
Abstract
α-Melanocyte stimulating hormone (α-MSH) and other melanocortin peptides are potent anti-inflammatory agents that exhibit efficacy in many animal models of acute and chronic inflammation. These peptides are produced both centrally and peripherally, and exert their biological actions via activation of membrane-bound receptors. To exploit the therapeutic potential of such anti-inflammatory peptides, it is essential that the receptor subtype mediating these effects is identified with certainty.
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