Regulatory T cells in alloreactivity after clinical heart transplantation
CC Baan, IE Dijke, W Weimar - Current opinion in organ …, 2009 - journals.lww.com
CC Baan, IE Dijke, W Weimar
Current opinion in organ transplantation, 2009•journals.lww.comThe studies in transplant patients' show that the function of CD4+ CD25 bright+ FoxP3+
regulatory T cells in alloimmunity is to inhibit the activation of effector T cells, to prevent
rejection, and to control the antidonor response at the graft itself at later stages of immune
reactivity.
regulatory T cells in alloimmunity is to inhibit the activation of effector T cells, to prevent
rejection, and to control the antidonor response at the graft itself at later stages of immune
reactivity.
Summary
The studies in transplant patients' show that the function of CD4+ CD25 bright+ FoxP3+ regulatory T cells in alloimmunity is to inhibit the activation of effector T cells, to prevent rejection, and to control the antidonor response at the graft itself at later stages of immune reactivity.
Lippincott Williams & Wilkins