Toll-like receptor 2 deficiency promotes the generation of alloreactive Th17 cells after cardiac transplantation in mice
L Li, X Chen, Y Zhang, Q Li, C Qi, X Fei, F Zheng… - Cellular …, 2019 - Elsevier
The emergence of alloreactive Th17 cells that mediate allograft rejection has provided an
impetus to understand the factors affecting the generation of Th17 cells in allograft
transplantation. How toll-like receptor 2 (TLR2) signalling regulates the generation of Th17
cells upon alloantigen stimuli remains unclear. In this study, we used a mouse model of
cardiac allograft transplantation to investigate whether TLR2 signalling influences the
development of Th17 cells. Here, we demonstrate that the TLR2-deficient recipient mice …
impetus to understand the factors affecting the generation of Th17 cells in allograft
transplantation. How toll-like receptor 2 (TLR2) signalling regulates the generation of Th17
cells upon alloantigen stimuli remains unclear. In this study, we used a mouse model of
cardiac allograft transplantation to investigate whether TLR2 signalling influences the
development of Th17 cells. Here, we demonstrate that the TLR2-deficient recipient mice …