CD4+ CD25+ regulatory T cells (TREG) in systemic lupus erythematosus (SLE) patients: the possible influence of treatment with corticosteroids
Systemic Lupus Erythematosus (SLE) is a chronic, systemic autoimmune disease
characterized by loss of tolerance to self-antigens. Regulatory T cells (TREG) are those
CD4+ T cells that constitutively express high levels of CD25 and exhibit powerful
suppressive properties. The aim of this work was to quantify CD4+ CD25+ (TREG) cells and
the Mean Fluorescence Index (MFI) of TREG in the peripheral blood of patients with SLE
and to correlate these findings with their disease activity scores and drug therapy. This study …
characterized by loss of tolerance to self-antigens. Regulatory T cells (TREG) are those
CD4+ T cells that constitutively express high levels of CD25 and exhibit powerful
suppressive properties. The aim of this work was to quantify CD4+ CD25+ (TREG) cells and
the Mean Fluorescence Index (MFI) of TREG in the peripheral blood of patients with SLE
and to correlate these findings with their disease activity scores and drug therapy. This study …