[HTML][HTML] TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB
ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) is known as a
multifunctional regulator in different signals, including Toll-like receptors (TLRs), TGF-β, and
BMP. Here, we report a new regulatory role of ECSIT in TLR4-mediated signal. By LPS
stimulation, ECSIT formed a high molecular endogenous complex including TAK1 and
TRAF6, in which ECSIT interacted with each protein and regulated TAK1 activity, leading to
the activation of NF-κB. ECSIT-knockdown THP-1 (ECSIT KD THP-1) cells exhibited severe …
multifunctional regulator in different signals, including Toll-like receptors (TLRs), TGF-β, and
BMP. Here, we report a new regulatory role of ECSIT in TLR4-mediated signal. By LPS
stimulation, ECSIT formed a high molecular endogenous complex including TAK1 and
TRAF6, in which ECSIT interacted with each protein and regulated TAK1 activity, leading to
the activation of NF-κB. ECSIT-knockdown THP-1 (ECSIT KD THP-1) cells exhibited severe …