[HTML][HTML] Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice
Cardiac hypertrophy and heart failure remain leading causes of death in the United States.
Many studies have suggested that, under stress, myocardium releases factors triggering
protein synthesis and stimulating myocyte growth. We identified and cloned myotrophin, a
12-kDa protein from hypertrophied human and rat hearts. Myotrophin (whose gene is
localized on human chromosome 7q33) stimulates myocyte growth and participates in
cellular interaction that initiates cardiac hypertrophy in vitro. In this report, we present data …
Many studies have suggested that, under stress, myocardium releases factors triggering
protein synthesis and stimulating myocyte growth. We identified and cloned myotrophin, a
12-kDa protein from hypertrophied human and rat hearts. Myotrophin (whose gene is
localized on human chromosome 7q33) stimulates myocyte growth and participates in
cellular interaction that initiates cardiac hypertrophy in vitro. In this report, we present data …