BACKGROUND: Specific myocardial mitochondrial enzymatic dysfunction and apoptotic
remodeling occur in pacing-induced heart failure. We sought to define their regional
distribution and molecular basis in the failing heart. METHODS AND RESULTS: Enzyme
dysfunction was assessed in mitochondrial subpopulations and immunoblot analysis was
performed using homogenate proteins from the left atria (LA) and left ventricle (LV) of paced
and control mongrel dogs. A greater range of enzymatic defects (complex I, III, and V) was …