[HTML][HTML] Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in …
NR Klatt, LD Harris, CL Vinton, H Sung, JA Briant… - Mucosal …, 2010 - Elsevier
Pigtail macaques (PTMs) rapidly progress to AIDS after simian immunodeficiency virus (SIV)
infection. Given the strong association between human immunodeficiency virus (HIV) and
SIV disease progression and microbial translocation and immune activation, we assessed
whether high basal levels of immune activation and microbial translocation exist in PTMs.
We found that before SIV infection, PTMs had high levels of microbial translocation that
correlated with significant damage to the structural barrier of the gastrointestinal tract …
infection. Given the strong association between human immunodeficiency virus (HIV) and
SIV disease progression and microbial translocation and immune activation, we assessed
whether high basal levels of immune activation and microbial translocation exist in PTMs.
We found that before SIV infection, PTMs had high levels of microbial translocation that
correlated with significant damage to the structural barrier of the gastrointestinal tract …