Robust suppression of env‐SHIV viremia in Macaca nemestrina by 3‐drug ART is independent of timing of initiation during chronic infection
CW Peterson, P Younan, PS Polacino… - Journal of medical …, 2013 - Wiley Online Library
Journal of medical primatology, 2013•Wiley Online Library
Background Nonhuman primates (NHP s) are an important model organism for studies of
HIV pathogenesis and preclinical evaluation of anti‐HIV therapies. The successful
translation of NHP‐derived data to clinically relevant anti‐HIV studies will require better
understanding of the viral strains and NHP species used and their responses to existing
antiretroviral therapies (ART). Methods Five pigtailed macaques (M acaca nemestrina) were
productively infected with the SIV/HIV chimeric virus SHIV‐1157 ipd3N4 following …
HIV pathogenesis and preclinical evaluation of anti‐HIV therapies. The successful
translation of NHP‐derived data to clinically relevant anti‐HIV studies will require better
understanding of the viral strains and NHP species used and their responses to existing
antiretroviral therapies (ART). Methods Five pigtailed macaques (M acaca nemestrina) were
productively infected with the SIV/HIV chimeric virus SHIV‐1157 ipd3N4 following …
Background
Nonhuman primates (NHPs) are an important model organism for studies of HIV pathogenesis and preclinical evaluation of anti‐HIV therapies. The successful translation of NHP‐derived data to clinically relevant anti‐HIV studies will require better understanding of the viral strains and NHP species used and their responses to existing antiretroviral therapies (ART).
Methods
Five pigtailed macaques (Macaca nemestrina) were productively infected with the SIV/HIV chimeric virus SHIV‐1157 ipd3N4 following intravenous challenge. After 8 or 27 weeks, ART (PMPA, FTC, raltegravir) was initiated. Viral load, T‐cell counts, and production of SHIV‐specific antibodies were monitored throughout the course of infection and ART.
Results
ART led to a rapid and sustained decrease in plasma viral load. Suppression of plasma viremia by ART was independent of the timing of initiation during chronic infection.
Conclusions
We present a new NHP model of HIV infection on antiretroviral therapy, which should prove applicable to multiple clinically relevant anti‐HIV approaches.
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