Retinoic acid in development: towards an integrated view
K Niederreither, P Dollé - Nature Reviews Genetics, 2008 - nature.com
K Niederreither, P Dollé
Nature Reviews Genetics, 2008•nature.comRetinoic acid (RA), the active form of vitamin A, is a small lipophilic molecule that acts as a
signalling molecule in vertebrates by binding to nuclear receptors (heterodimers of RA
receptors and retinoid X receptors; RAR–RXR) and regulating the transcriptional activity of
various target genes.The distribution of RA is tightly controlled in embryonic tissues. Its
synthesis from inactive precursors (retinol or beta-carotene) is mediated by retinaldehyde
dehydrogenases 1 to 3 (RALDH1 to RALDH3), and a group of cytochrome P450s (the …
signalling molecule in vertebrates by binding to nuclear receptors (heterodimers of RA
receptors and retinoid X receptors; RAR–RXR) and regulating the transcriptional activity of
various target genes.The distribution of RA is tightly controlled in embryonic tissues. Its
synthesis from inactive precursors (retinol or beta-carotene) is mediated by retinaldehyde
dehydrogenases 1 to 3 (RALDH1 to RALDH3), and a group of cytochrome P450s (the …
Retinoic acid (RA), the active form of vitamin A, is a small lipophilic molecule that acts as a signalling molecule in vertebrates by binding to nuclear receptors (heterodimers of RA receptors and retinoid X receptors; RAR–RXR) and regulating the transcriptional activity of various target genes.
The distribution of RA is tightly controlled in embryonic tissues. Its synthesis from inactive precursors (retinol or beta-carotene) is mediated by retinaldehyde dehydrogenases 1 to 3 (RALDH1 to RALDH3), and a group of cytochrome P450s (the cytochrome P450 26 enzymes CYP26A1 to CYP26C1) trigger its tissue-specific catabolism. Both types of enzymes are often expressed according to mutually exclusive, complementary patterns.
nature.com