[HTML][HTML] Flt-1 (VEGFR-1) is essential for the VEGF-Notch feedback loop during angiogenesis
JC Chappell, KP Mouillesseaux… - … thrombosis, and vascular …, 2013 - ncbi.nlm.nih.gov
JC Chappell, KP Mouillesseaux, VL Bautch
Arteriosclerosis, thrombosis, and vascular biology, 2013•ncbi.nlm.nih.govObjective Vascular endothelial growth factor (VEGF) signaling induces Notch signaling
during angiogenesis. Flt-1/VEGF receptor-1 (VEGFR-1) negatively modulates VEGF
signaling. Therefore, we tested the hypothesis that disrupted Flt-1 regulation of VEGF
signaling causes Notch pathway defects that contribute to dysmorphogenesis of Flt-1 mutant
vessels.
during angiogenesis. Flt-1/VEGF receptor-1 (VEGFR-1) negatively modulates VEGF
signaling. Therefore, we tested the hypothesis that disrupted Flt-1 regulation of VEGF
signaling causes Notch pathway defects that contribute to dysmorphogenesis of Flt-1 mutant
vessels.
Abstract
Objective
Vascular endothelial growth factor (VEGF) signaling induces Notch signaling during angiogenesis. Flt-1/VEGF receptor-1 (VEGFR-1) negatively modulates VEGF signaling. Therefore, we tested the hypothesis that disrupted Flt-1 regulation of VEGF signaling causes Notch pathway defects that contribute to dysmorphogenesis of Flt-1 mutant vessels.
ncbi.nlm.nih.gov