Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency
Y Xie, EP Newberry, SG Young, S Robine… - Journal of Biological …, 2006 - jbc.org
Microsomal TG transfer protein (MTTP) is required for the assembly and secretion of TG (TG)-
rich lipoproteins from both enterocytes and hepatocytes. Liver-specific deletion of Mttp
produced a dramatic reduction in plasma very low density lipoprotein-TG and virtually
eliminated apolipoprotein B100 (apoB100) secretion yet caused only modest reductions in
plasma apoB48 and apoB48 secretion from primary hepatocytes. These observations
prompted us to examine the phenotype following intestine-specific Mttp deletion because …
rich lipoproteins from both enterocytes and hepatocytes. Liver-specific deletion of Mttp
produced a dramatic reduction in plasma very low density lipoprotein-TG and virtually
eliminated apolipoprotein B100 (apoB100) secretion yet caused only modest reductions in
plasma apoB48 and apoB48 secretion from primary hepatocytes. These observations
prompted us to examine the phenotype following intestine-specific Mttp deletion because …
