Objective: It has been suggested that fluid accumulation may delay recognition of acute
kidney injury. We sought to determine the impact of fluid balance on the incidence of
nondialysis requiring acute kidney injury in patients with acute lung injury and to describe
associated outcomes, including mortality. Design: Analysis of the Fluid and Catheter
Treatment Trial, a factorial randomized clinical trial of conservative vs. liberal fluid
management and of management guided by a central venous vs. pulmonary artery catheter …