[HTML][HTML] Differential phosphorylation of c-Jun and JunD in response to the epidermal growth factor is determined by the structure of MAPK targeting sequences
M Vinciguerra, A Vivacqua, G Fasanella, A Gallo… - Journal of Biological …, 2004 - ASBMB
MAPK phosphorylation of various substrates is mediated by the presence of docking sites,
including the D domain and the DEF motif. Depending on the number and sequences of
these domains, substrates are phosphorylated by specific subsets of MAPKs. For example, a
D domain targets JNK to c-Jun, whereas a DEF motif is required for ERK phosphorylation of
c-Fos. JunD, in contrast, contains both D and DEF domains. Here we show that these motifs
mediate JunD phosphorylation in response to either ERK or JNK activation. An intact D …
including the D domain and the DEF motif. Depending on the number and sequences of
these domains, substrates are phosphorylated by specific subsets of MAPKs. For example, a
D domain targets JNK to c-Jun, whereas a DEF motif is required for ERK phosphorylation of
c-Fos. JunD, in contrast, contains both D and DEF domains. Here we show that these motifs
mediate JunD phosphorylation in response to either ERK or JNK activation. An intact D …
