[HTML][HTML] Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in …
S Eguchi, K Numaguchi, H Iwasaki, T Matsumoto… - Journal of Biological …, 1998 - ASBMB
We have recently reported that angiotensin II (Ang II)-induced mitogen-activated protein
kinase (MAPK) activation is mainly mediated by Ca 2+-dependent activation of a protein
tyrosine kinase through G q-coupled Ang II type 1 receptor in cultured rat vascular smooth
muscle cells (VSMC). In the present study, we found Ang II rapidly induced the tyrosine
phosphorylation of the epidermal growth factor (EGF) receptor and its association with Shc
and Grb2. These reactions were inhibited by the EGF receptor kinase inhibitor, AG1478. The …
kinase (MAPK) activation is mainly mediated by Ca 2+-dependent activation of a protein
tyrosine kinase through G q-coupled Ang II type 1 receptor in cultured rat vascular smooth
muscle cells (VSMC). In the present study, we found Ang II rapidly induced the tyrosine
phosphorylation of the epidermal growth factor (EGF) receptor and its association with Shc
and Grb2. These reactions were inhibited by the EGF receptor kinase inhibitor, AG1478. The …