Biogenesis, trafficking and up-regulation of nicotinic ACh receptors
SF Colombo, F Mazzo, F Pistillo, C Gotti - Biochemical pharmacology, 2013 - Elsevier
SF Colombo, F Mazzo, F Pistillo, C Gotti
Biochemical pharmacology, 2013•ElsevierChronic nicotine exposure gives rise to neural adaptations that change whole cell
physiology and behaviour mainly by interacting with neuronal nicotinic acetylcholine
receptors (nAChRs). The major nicotine-induced neuroadaptation is the up-regulation of
brain nAChRs by means of cell-delimited post-translational mechanisms. We review what is
known of the processes regulating nAChR assembly, degradation and trafficking, and how
nicotine-induced modulation of these processes leads to nAChR up-regulation and changes …
physiology and behaviour mainly by interacting with neuronal nicotinic acetylcholine
receptors (nAChRs). The major nicotine-induced neuroadaptation is the up-regulation of
brain nAChRs by means of cell-delimited post-translational mechanisms. We review what is
known of the processes regulating nAChR assembly, degradation and trafficking, and how
nicotine-induced modulation of these processes leads to nAChR up-regulation and changes …
Abstract
Chronic nicotine exposure gives rise to neural adaptations that change whole cell physiology and behaviour mainly by interacting with neuronal nicotinic acetylcholine receptors (nAChRs).
The major nicotine-induced neuroadaptation is the up-regulation of brain nAChRs by means of cell-delimited post-translational mechanisms. We review what is known of the processes regulating nAChR assembly, degradation and trafficking, and how nicotine-induced modulation of these processes leads to nAChR up-regulation and changes in downstream neuronal plasticity at molecular, cellular and circuit level.
Elsevier