[HTML][HTML] Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2· TIMP-2 complex through a thrombospondin-independent …
H Emonard, G Bellon, L Troeberg, A Berton… - Journal of Biological …, 2004 - ASBMB
The low density lipoprotein receptor-related protein (LRP) mediates the endocytic clearance
of various proteinases and proteinase· inhibitor complexes, including thrombospondin (TSP)-
dependent endocytosis of matrix metalloproteinase (MMP)-2 (or gelatinase A), a key effector
of extracellular matrix remodeling and cancer progression. However, the zymogen of MMP-2
(pro-MMP-2) mostly occurs in tissues as a complex with the tissue inhibitor of MMPs (TIMP-
2). Here we show that clearance of the pro-MMP-2· TIMP-2 complex is also mediated by …
of various proteinases and proteinase· inhibitor complexes, including thrombospondin (TSP)-
dependent endocytosis of matrix metalloproteinase (MMP)-2 (or gelatinase A), a key effector
of extracellular matrix remodeling and cancer progression. However, the zymogen of MMP-2
(pro-MMP-2) mostly occurs in tissues as a complex with the tissue inhibitor of MMPs (TIMP-
2). Here we show that clearance of the pro-MMP-2· TIMP-2 complex is also mediated by …