Toll-like receptor stimulation in cancer: a pro-and anti-tumor double-edged sword

M Dajon, K Iribarren, I Cremer - Immunobiology, 2017 - Elsevier
Toll-like receptors (TLRs) are a family of transmembrane receptors that recognize various
pathogen-and damage-associated molecular pattern molecules playing an important role in
inflammation by activating NF-кB. TLRs, mainly expressed by innate immune cells, are
involved in inducing and regulating adaptive immune responses. However, the expression
of TLRs has also been observed in many tumors, and their stimulation results in tumor
progression or regression, depending on the TLR and tumor type. Here we review the role of …