Phenotypic and Ig repertoire analyses indicate a common origin of IgD− CD27− double negative B cells in healthy individuals and multiple sclerosis patients

J Fraussen, S Marquez, K Takata, L Beckers… - The Journal of …, 2019 - journals.aai.org
J Fraussen, S Marquez, K Takata, L Beckers, G Montes Diaz, C Zografou, B Van Wijmeersch…
The Journal of Immunology, 2019journals.aai.org
The study was directed by the coprincipal investigators, KCO, SHK, and VS The
investigation of the MS DN repertoire was initially conceived by VS and JF The overall
experimental design was developed by JF, KCO, SHK, and VS Patient and control
identification, recruitment, and FACS-based phenotyping and cell sorting were performed by
JF, LB, GMD, BVW, and LMV Support for the sequencing and cell sorting was obtained by
and awarded to KCO Generation of the sequencing libraries was performed by KT, CZ, and …
The study was directed by the coprincipal investigators, KCO, SHK, and VS The investigation of the MS DN repertoire was initially conceived by VS and JF The overall experimental design was developed by JF, KCO, SHK, and VS Patient and control identification, recruitment, and FACS-based phenotyping and cell sorting were performed by JF, LB, GMD, BVW, and LMV Support for the sequencing and cell sorting was obtained by and awarded to KCO Generation of the sequencing libraries was performed by KT, CZ, and KCO The sequencing data were processed, analyzed, and interpreted by SM and SHK The manuscript was written by JF, KCO, SHK, and VS and edited through contributions by all of the authors.
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