[HTML][HTML] Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex
A Klyuyeva, A Tuganova, N Kedishvili… - Journal of Biological …, 2019 - ASBMB
The pyruvate dehydrogenase complex (PDC) is a multienzyme assembly that converts
pyruvate to acetyl-CoA. As pyruvate and acetyl-CoA play central roles in cellular
metabolism, understanding PDC regulation is pivotal to understanding the larger metabolic
network. The activity of mammalian PDC is regulated through reversible phosphorylation
governed by at least four isozymes of pyruvate dehydrogenase kinase (PDK). Deciphering
which kinase regulates PDC in organisms at specific times or places has been challenging …
pyruvate to acetyl-CoA. As pyruvate and acetyl-CoA play central roles in cellular
metabolism, understanding PDC regulation is pivotal to understanding the larger metabolic
network. The activity of mammalian PDC is regulated through reversible phosphorylation
governed by at least four isozymes of pyruvate dehydrogenase kinase (PDK). Deciphering
which kinase regulates PDC in organisms at specific times or places has been challenging …