[HTML][HTML] Modification of CCAAT/enhancer-binding protein-β by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3
EM Eaton, L Sealy - Journal of Biological Chemistry, 2003 - ASBMB
CCAAT/enhancer-binding protein-β (C/EBPβ) activator isoforms, C/EBPβ-1 and C/EBPβ-2,
differ by only 23 amino acids in the human; however, evidence is accumulating that these
transcription factors are functionally distinct. Here we demonstrate that C/EBPβ-1, but not
C/EBPβ-2, is conjugated to the small ubiquitin-like modifier (SUMO) family members, SUMO-
2 and SUMO-3 despite the fact that the SUMO target consensus is present in both isoforms
of this transcription factor. This conjugation is dependent on the integrity of the extreme N …
differ by only 23 amino acids in the human; however, evidence is accumulating that these
transcription factors are functionally distinct. Here we demonstrate that C/EBPβ-1, but not
C/EBPβ-2, is conjugated to the small ubiquitin-like modifier (SUMO) family members, SUMO-
2 and SUMO-3 despite the fact that the SUMO target consensus is present in both isoforms
of this transcription factor. This conjugation is dependent on the integrity of the extreme N …