Notch signaling confers antigen-presenting cell functions on mast cells

N Nakano, C Nishiyama, H Yagita, A Koyanagi… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: Notch signaling is involved in cell fate determination along with the
development of the immune system. However, very little is known about the role for Notch
signaling in mast cells. OBJECTIVE: We investigated the role of Notch signaling in mast cell
functions. METHODS: After mouse bone marrow–derived mast cells (BMMCs) or peritoneal
mast cells (PMCs) were cocultured with mouse Notch ligand-expressing chinese hamster
ovary cells for 5 days, we examined the mast cell surface expressions of MHC-II molecules …