Coordinated circulating T follicular helper and activated B cell responses underlie the onset of antibody-mediated rejection in kidney transplantation
K Louis, C Macedo, E Bailly, L Lau… - Journal of the …, 2020 - journals.lww.com
Background Although antibody-mediated rejection (ABMR) has been long recognized as a
leading cause of allograft failure after kidney transplantation, the cellular and molecular
processes underlying the induction of deleterious donor-specific antibody (DSA) responses
remain poorly understood. Methods Using high-dimensional flow cytometry, in vitro assays,
and RNA sequencing, we concomitantly investigated the role of T follicular helper (T FH)
cells and B cells during ABMR in 105 kidney transplant recipients. Results There were 54 …
leading cause of allograft failure after kidney transplantation, the cellular and molecular
processes underlying the induction of deleterious donor-specific antibody (DSA) responses
remain poorly understood. Methods Using high-dimensional flow cytometry, in vitro assays,
and RNA sequencing, we concomitantly investigated the role of T follicular helper (T FH)
cells and B cells during ABMR in 105 kidney transplant recipients. Results There were 54 …