A growing body of evidence suggests that when B cells are chronically stimulated, a
phenotypically unique subset expands. Data suggest that this atypical population contains B
cell receptor (BCR) specificities capable of binding the antigen, or sets of antigens that
initiated the expansion of these cells. These B cells have been given various names,
including double negative B cells, atypical memory B cells, tissue-like memory B cells, or
age associated B cells (ABCs). However, on close inspection these reports described B cell …