AKI is associated with high morbidity and mortality, and it predisposes to the development
and progression of CKD. Novel strategies that minimize AKI and halt the progression of CKD
are urgently needed. Normal kidney function involves numerous different cell types, such as
tubular epithelial cells, endothelial cells, and podocytes, working in concert. This delicate
balance involves many energy-intensive processes. Fatty acids are the preferred energy
substrates for the kidney, and defects in fatty acid oxidation and mitochondrial dysfunction …