[HTML][HTML] Eotaxin and the attraction of eosinophils to the asthmatic lung

DM Conroy, TJ Williams - Respiratory research, 2001 - Springer
DM Conroy, TJ Williams
Respiratory research, 2001Springer
Eosinophilic leukocytes accumulate in high numbers in the lungs of asthmatic patients, and
are believed to be important in the pathogenisis of asthma. A potent eosinophil
chemoattractant is produced in the asthmatic lung. This small protein, the chemokine
eotaxin, is synthesized by a number of different cell types, and is stimulated by interleukin-4
and interleukin-13, which are produced by T-helper (Th) 2 lymphocytes. Low molecular
weight compounds have been developed that can block the eotaxin receptor CC chemokine …
Abstract
Eosinophilic leukocytes accumulate in high numbers in the lungs of asthmatic patients, and are believed to be important in the pathogenisis of asthma. A potent eosinophil chemoattractant is produced in the asthmatic lung. This small protein, the chemokine eotaxin, is synthesized by a number of different cell types, and is stimulated by interleukin-4 and interleukin-13, which are produced by T-helper (Th)2 lymphocytes. Low molecular weight compounds have been developed that can block the eotaxin receptor C-C chemokine receptor (CCR)3, and prevent stimulation by eotaxin. This provides the potential for orally available drugs that can prevent eosinophil recruitment into the lung and the associated damage and dysfunction.
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