Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

JL Barlow, A Bellosi, CS Hardman, LF Drynan… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: IL-4, IL-5, and IL-13 are thought to be central to the allergic asthmatic
response. Previous work supposed that the essential source of these cytokines was CD4+
TH2 cells. However, more recent studies have suggested that other innate production of type
2 cytokines might be as important. OBJECTIVES: Nuocytes are a novel population of IL-13–
producing innate cells, which are critical for protective immunity in Nippostrongylus
brasiliensis infection. Given this, we investigated the potential existence and functional …