Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients
Background Group 2 innate lymphoid cells (ILC2s) are effective producers of IL-5 and IL-13
during allergic inflammation and bridge the innate and adaptive immune responses. ILC2
numbers are increased in asthmatic patients compared with healthy control subjects. Thus
far, human data describing their phenotype during acute allergic inflammation in the lung
are incomplete. Objectives This study aims to characterize and compare blood-and lung-
derived ILC2s before and after segmental allergen challenge in patients with mild-to …
during allergic inflammation and bridge the innate and adaptive immune responses. ILC2
numbers are increased in asthmatic patients compared with healthy control subjects. Thus
far, human data describing their phenotype during acute allergic inflammation in the lung
are incomplete. Objectives This study aims to characterize and compare blood-and lung-
derived ILC2s before and after segmental allergen challenge in patients with mild-to …