Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect
JE Gerich, M Langlois, C Noacco, JH Karam… - Science, 1973 - science.org
JE Gerich, M Langlois, C Noacco, JH Karam, PH Forsham
Science, 1973•science.orgDespite excessive glucagon responses to infusion of arginine, plasma glucagon did not rise
in six juvenile-type diabetics during severe insulin-induced hypoglycemia, whereas
glucagon in the controls rose significantly. Thus in diabetics pancreatic alpha cells are
insensitive to glucose even in the presence of large amounts of circulating insulin. An
intrinsic defect common to both alpha and beta pancreatic cells—failure to recognize (or
respond to) plasma glucose fluctuations—may be operative in juvenile diabetes.
in six juvenile-type diabetics during severe insulin-induced hypoglycemia, whereas
glucagon in the controls rose significantly. Thus in diabetics pancreatic alpha cells are
insensitive to glucose even in the presence of large amounts of circulating insulin. An
intrinsic defect common to both alpha and beta pancreatic cells—failure to recognize (or
respond to) plasma glucose fluctuations—may be operative in juvenile diabetes.
Despite excessive glucagon responses to infusion of arginine, plasma glucagon did not rise in six juvenile-type diabetics during severe insulin-induced hypoglycemia, whereas glucagon in the controls rose significantly. Thus in diabetics pancreatic alpha cells are insensitive to glucose even in the presence of large amounts of circulating insulin. An intrinsic defect common to both alpha and beta pancreatic cells—failure to recognize (or respond to) plasma glucose fluctuations—may be operative in juvenile diabetes.
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