Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury

G Schley, B Klanke, J Schödel… - Journal of the …, 2011 - journals.lww.com
Hypoxia-inducible transcription factors (HIF) protect cells against oxygen deprivation, and
HIF stabilization before ischemia mitigates tissue injury. Because ischemic acute kidney
injury (AKI) often involves the thick ascending limb (TAL), modulation of HIF in this segment
may be protective. Here, we generated mice with targeted TAL deletion of the von Hippel-
Lindau protein (Vhl), which mediates HIF degradation under normoxia, using Tamm-Horsfall
protein (Thp)-driven Cre expression. These mice showed strong expression of HIF-1α in …