MCP-1 gene activation marks acute kidney injury
R Munshi, A Johnson, ED Siew, TA Ikizler… - Journal of the …, 2011 - journals.lww.com
Abstract Monocyte chemoattractant protein 1 (MCP-1) mediates acute ischemic and toxic
kidney injury, but whether this can be used as a biomarker of acute kidney injury (AKI) is
unknown. We obtained kidney and urine samples from mice with intrarenal (maleate),
prerenal (endotoxemia), or postrenal (ureteral obstruction) injury. We also studied the
independent effects of uremia without concomitant kidney injury by performing bilateral
ureteral transection in mice. Additionally, we obtained urine samples from APACHE II …
kidney injury, but whether this can be used as a biomarker of acute kidney injury (AKI) is
unknown. We obtained kidney and urine samples from mice with intrarenal (maleate),
prerenal (endotoxemia), or postrenal (ureteral obstruction) injury. We also studied the
independent effects of uremia without concomitant kidney injury by performing bilateral
ureteral transection in mice. Additionally, we obtained urine samples from APACHE II …