[HTML][HTML] Acyl-CoA synthetases as regulators of brain phospholipid acyl-chain diversity

RF Fernandez, JM Ellis - Prostaglandins, Leukotrienes and Essential Fatty …, 2020 - Elsevier
Each individual cell-type is defined by its distinct morphology, phenotype, molecular and
lipidomic profile. The importance of maintaining cell-specific lipidomic profiles is exemplified
by the numerous diseases, disorders, and dysfunctional outcomes that occur as a direct
result of altered lipidome. Therefore, the mechanisms regulating cellular lipidome diversity
play a role in maintaining essential biological functions. The brain is an organ particularly
rich in phospholipids, the main constituents of cellular membranes. The phospholipid acyl …