Acyl-coenzyme A synthetases in metabolic control
JM Ellis, JL Frahm, LO Li… - Current opinion in …, 2010 - journals.lww.com
JM Ellis, JL Frahm, LO Li, RA Coleman
Current opinion in lipidology, 2010•journals.lww.comFuture studies are required to determine the subcellular location of each ACSL and ACSVL
isoform and the functional importance of phosphorylation and acetylation. Purification and
crystallization of mammalian ACSL and ACSVL isoforms is needed to confirm the
mechanism of action and discover how these enzymes differ in their affinity for fatty acids of
different chain lengths. Functionally, it will be important to learn how the ACSL isoforms can
direct their acyl-CoA products toward independent downstream pathways.
isoform and the functional importance of phosphorylation and acetylation. Purification and
crystallization of mammalian ACSL and ACSVL isoforms is needed to confirm the
mechanism of action and discover how these enzymes differ in their affinity for fatty acids of
different chain lengths. Functionally, it will be important to learn how the ACSL isoforms can
direct their acyl-CoA products toward independent downstream pathways.
Summary
Future studies are required to determine the subcellular location of each ACSL and ACSVL isoform and the functional importance of phosphorylation and acetylation. Purification and crystallization of mammalian ACSL and ACSVL isoforms is needed to confirm the mechanism of action and discover how these enzymes differ in their affinity for fatty acids of different chain lengths. Functionally, it will be important to learn how the ACSL isoforms can direct their acyl-CoA products toward independent downstream pathways.
Lippincott Williams & Wilkins