[HTML][HTML] A Mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-κB activity and cytokine secretion in macrophages via the activation of mitogen …
J Garcia, B Lemercier, S Roman-Roman… - journal of Biological …, 1998 - ASBMB
Mycoplasma lipoproteins have been demonstrated to stimulate monocytic cells and induce
proinflammatory cytokine secretion. In this paper, we show that a synthetic analog of
theMycoplasma fermentans membrane-associated lipopeptide macrophage-activating
lipopeptide-2 (MALP-2) induces mRNA synthesis and protein secretion of interleukin-1β and
tumor necrosis factor-α in human monocytes/macrophages and the murine macrophage cell
line RAW 264.7, whereas the nonlipidated counterpart lacks this effect, underscoring the …
proinflammatory cytokine secretion. In this paper, we show that a synthetic analog of
theMycoplasma fermentans membrane-associated lipopeptide macrophage-activating
lipopeptide-2 (MALP-2) induces mRNA synthesis and protein secretion of interleukin-1β and
tumor necrosis factor-α in human monocytes/macrophages and the murine macrophage cell
line RAW 264.7, whereas the nonlipidated counterpart lacks this effect, underscoring the …