Inhibition of p38 MAP kinase as a therapeutic strategy
JC Lee, S Kumar, DE Griswold, DC Underwood… - …, 2000 - Elsevier
Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has
progressed dramatically. The key advances include (1) identification of p38 MAP kinase
homologs and protein kinases that act upstream and downstream from p38 MAP kinase,(2)
identification of interesting and potentially important substrates,(3) elucidation of the role of
p38 MAP kinase in cellular processes and (4) the establishment of the mechanism by which
the pyridinylimidazole p38 MAP kinase inhibitors inhibit enzyme activity. It is now known that …
progressed dramatically. The key advances include (1) identification of p38 MAP kinase
homologs and protein kinases that act upstream and downstream from p38 MAP kinase,(2)
identification of interesting and potentially important substrates,(3) elucidation of the role of
p38 MAP kinase in cellular processes and (4) the establishment of the mechanism by which
the pyridinylimidazole p38 MAP kinase inhibitors inhibit enzyme activity. It is now known that …