[HTML][HTML] Validation of circulating steroid hormone measurements across different matrices by liquid chromatography–tandem mass spectrometry

G Snaterse, LF van Dessel, AE Taylor, JA Visser, W Arlt… - Steroids, 2021 - Elsevier
Background Steroid hormones are essential signalling molecules in prostate cancer (PC).
However, many studies focusing on liquid biomarkers fail to take the hormonal status of
these patients into account. Steroid measurements are sensitive to bias caused by matrix
effects, thus assessing potential matrix effects is an important step in combining circulating
tumour DNA (ctDNA) analysis with hormone status. Methods We investigated the accuracy
of multi-steroid hormone profiling in mechanically-separated plasma (MSP) samples and in …