Hypoxia-independent downregulation of hypoxia-inducible factor 1 targets by androgen deprivation therapy in prostate cancer
HB Ragnum, K Rĝe, R Holm, L Vlatkovic… - International Journal of …, 2013 - Elsevier
Purpose We explored changes in hypoxia-inducible factor 1 (HIF1) signaling during
androgen deprivation therapy (ADT) of androgen-sensitive prostate cancer xenografts under
conditions in which no significant change in immunostaining of the hypoxia marker
pimonidazole had occurred. Methods and Materials Gene expression profiles of volume-
matched androgen-exposed and androgen-deprived CWR22 xenografts, with similar
pimonidazole-positive fractions, were compared. Direct targets of androgen receptor (AR) …
androgen deprivation therapy (ADT) of androgen-sensitive prostate cancer xenografts under
conditions in which no significant change in immunostaining of the hypoxia marker
pimonidazole had occurred. Methods and Materials Gene expression profiles of volume-
matched androgen-exposed and androgen-deprived CWR22 xenografts, with similar
pimonidazole-positive fractions, were compared. Direct targets of androgen receptor (AR) …