Role of epigenetic mechanisms regulated by enhancers and long noncoding RNAs in cardiovascular disease

S Das, MA Reddy, R Natarajan - Current opinion in cardiology, 2020 - journals.lww.com
S Das, MA Reddy, R Natarajan
Current opinion in cardiology, 2020journals.lww.com
Epigenomic approaches in cells affected in CVDs can be exploited to understand the
function of genetic polymorphisms at cis-regulatory elements and crosstalk between
enhancers and lncRNAs associated with disease susceptibility and progression. The
reversible nature of epigenetics provides opportunities for the development of novel
therapeutic strategies for CVD.
Summary
Epigenomic approaches in cells affected in CVDs can be exploited to understand the function of genetic polymorphisms at cis-regulatory elements and crosstalk between enhancers and lncRNAs associated with disease susceptibility and progression. The reversible nature of epigenetics provides opportunities for the development of novel therapeutic strategies for CVD.
Lippincott Williams & Wilkins