Targeting inflammation in the treatment of type 2 diabetes: time to start

MY Donath - Nature reviews Drug discovery, 2014 - nature.com
Nature reviews Drug discovery, 2014nature.com
The role of inflammation in the pathogenesis of type 2 diabetes and associated
complications is now well established. Several conditions that are driven by inflammatory
processes are also associated with diabetes, including rheumatoid arthritis, gout, psoriasis
and Crohn's disease, and various anti-inflammatory drugs have been approved or are in late
stages of development for the treatment of these conditions. This Review discusses the
rationale for the use of some of these anti-inflammatory treatments in patients with diabetes …
Abstract
The role of inflammation in the pathogenesis of type 2 diabetes and associated complications is now well established. Several conditions that are driven by inflammatory processes are also associated with diabetes, including rheumatoid arthritis, gout, psoriasis and Crohn's disease, and various anti-inflammatory drugs have been approved or are in late stages of development for the treatment of these conditions. This Review discusses the rationale for the use of some of these anti-inflammatory treatments in patients with diabetes and what we could expect from their use. Future immunomodulatory treatments may not target a specific disease, but could instead act on a dysfunctional pathway that causes several conditions associated with the metabolic syndrome.
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