While the mouse retina has emerged as an important genetic model for inherited retinal
disease, the mouse vitreous remains to be explored. The vitreous is a highly aqueous
extracellular matrix overlying the retina where intraocular as well as extraocular proteins
accumulate during disease. 1-3 Abnormal interactions between vitreous and retina underlie
several diseases such as retinal detachment, proliferative diabetic retinopathy, uveitis, and
proliferative vitreoretinopathy. 1, 4 The relative mouse vitreous volume is significantly …