SOCS3 negatively regulates LIF signaling in neural precursor cells
Cytokines that signal through the LIFRβ/gp130 receptor complex, including LIF and CNTF,
promote the self-renewal of embryonic and adult neural precursor cells (NPCs). In non-CNS
tissues, the protein suppressor of cytokine signaling-3 (SOCS3) negatively regulates
signaling through gp130. Here, we analyze the role of SOCS3 in inhibiting LIF signaling in
NPCs in vitro. SOCS3 is rapidly expressed by NPCs in response to LIF stimulation, with this
expression largely dependent on recruitment of STAT proteins to the activated gp130 …
promote the self-renewal of embryonic and adult neural precursor cells (NPCs). In non-CNS
tissues, the protein suppressor of cytokine signaling-3 (SOCS3) negatively regulates
signaling through gp130. Here, we analyze the role of SOCS3 in inhibiting LIF signaling in
NPCs in vitro. SOCS3 is rapidly expressed by NPCs in response to LIF stimulation, with this
expression largely dependent on recruitment of STAT proteins to the activated gp130 …