Inflammatory pathways in alcoholic steatohepatitis

B Gao, MF Ahmad, LE Nagy, H Tsukamoto - Journal of hepatology, 2019 - Elsevier
Inflammatory processes are primary contributors to the development and progression of
alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non-
resolving inflammation. Inflammation in the progression of ASH is a complex response to
microbial dysbiosis, loss of barrier integrity in the intestine, hepatocellular stress and death,
as well as inter-organ crosstalk. Herein, we review the roles of multiple cell types that are
involved in inflammation in ASH, including resident macrophages and infiltrating monocytes …